Non-genetic mechanisms of therapeutic resistance in cancer

Jean-Christoph Marine, Sarah-Jane Dawson & Mark A. Dawson

Cancer relapse from minimal residual disease (MRD)

• clonal evolution (genetic mechanisms) -> Known
• Non-genetic mechanisms -> Remain largely unknown

Therapeutic resistance in cancer

Resistance is:

Primary	Secondary
Intrinsic	Acquired
lack of clinical response after therapy	local or distant reccurence of the malignancy after therapy

Secondary resistance:

• Genetic evolution