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• Inhibition of ubiquitin-specific protease 7 sensitizes acute myeloid leukemia to chemotherapy

• The oncometabolite R-2-hydroxyglutarate activates NF-κB-dependent tumor-promoting stromal niche for acute myeloid leukemia cells

• Mutant IDH: a targetable driver of leukemic phenotypes linking metabolism, epigenetics and transcriptional regulation

• Inhibition of mitochondrial translation overcomes venetoclax resistance in AML through activation of the integrated stress response

• 2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity

• Rapid Conversion of Mutant IDH1 from Driver to Passenger in a Model of Human Gliomagenesis

• The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism

• Triptolide suppresses IDH1-mutated malignancy via Nrf2-driven glutathione metabolism