Teams working on epigenetic

• Els Verhoeyen, GADPH over-expression in the T cell lineage leads to a rare T cell lymphoma through a NF-kB dependant mechanism

• Claire Francastel, DNA methylation, satellite repeats and genome stability: challenges and perspectives from rare genetic disorders

Els Verhoeyen, GADPH over-expression in the T cell lineage leads to a rare T cell lymphoma through a NF-kB dependant mechanism

RELA is a subunit of NF-KB that is found in our analysis.

What’s important here?

• GADPH induced non canonical NF-kB pathway activation
• inhibition of NF-kB –> increased survival of angioimmunoblastic T cell lymphoma (AITL)

Claire Francastel, DNA methylation, satellite repeats and genome stability: challenges and perspectives from rare genetic disorders

• Repeated sequences -> Genome instability like in stress, aging or cancer. Looking at DNAme